Dopaminergic deficit is not the rule in orthostatic tremor
Identifieur interne : 000294 ( France/Analysis ); précédent : 000293; suivant : 000295Dopaminergic deficit is not the rule in orthostatic tremor
Auteurs : Jean-Marc Trocello [France] ; Paolo Zanotti-Fregonara [France] ; Emmanuel Roze [France] ; Emmanuelle Apartis [France] ; André-Pierre Legrand [France] ; Marie-Odile Habert [France] ; Jean-Yves Devaux [France] ; Marie Vidailhet [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-09-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Brain Mapping, Dopamine (deficiency), Dopamine (physiology), Electromyography, Female, Humans, Male, Middle Aged, Nervous system diseases, Neurophysiology, Parkinson disease, Parkinson's disease, Pathophysiology, Photon, Prognosis, SPECT, Single photon emission tomography, Tomography, Emission-Computed, Single-Photon (methods), Tremor, Tremor (drug therapy), Tremor (physiopathology), Tremor (radionuclide imaging), Tropanes (diagnostic use), neurophysiology, orthostatic tremor, pathophysiology, prognosis.
- MESH :
- chemical , deficiency : Dopamine.
- chemical , diagnostic use : Tropanes.
- chemical , physiology : Dopamine.
- drug therapy : Tremor.
- methods : Tomography, Emission-Computed, Single-Photon.
- physiopathology : Tremor.
- radionuclide imaging : Tremor.
- Aged, Brain Mapping, Electromyography, Female, Humans, Male, Middle Aged.
Abstract
Involvement of the dopaminergic system in orthostatic tremor is controversial. The aim of this study was to detect possible dopaminergic denervation in primary orthostatic tremor (OT). Twelve consecutive patients with a firm diagnosis of primary orthostatic tremor were compared with age‐matched normal controls. All the patients had a neurological examination, surface polymyography, and quantification of striatal dopamine transporters with 123I‐FP‐CIT SPECT imaging. There was no significant difference in 123I‐FP‐CIT SPECT findings between controls and patients with OT. Longstanding primary orthostatic tremor is not necessarily associated with 123I‐FP‐CIT SPECT abnormalities, as 8 of our patients had more than a 10‐year history of OT. Primary orthostatic tremor without dopaminergic denervation remains a valid entity, although representing only a subtype of high‐frequency OT. A new role may emerge for 123I‐FP‐CIT SPECT in distinguishing between patients whose symptoms will be restricted to OT throughout the disease course and patients at an increased risk of developing PD. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22224
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-09-15">2008-09-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1733">1733</biblScope><biblScope unit="page" to="1738">1738</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">03E3817B00977D09B9076DF12E98B3BA13AB60F4</idno><idno type="DOI">10.1002/mds.22224</idno><idno type="ArticleID">MDS22224</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Dopamine (deficiency)</term><term>Dopamine (physiology)</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neurophysiology</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Pathophysiology</term><term>Photon</term><term>Prognosis</term><term>SPECT</term><term>Single photon emission tomography</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tremor</term><term>Tremor (drug therapy)</term><term>Tremor (physiopathology)</term><term>Tremor (radionuclide imaging)</term><term>Tropanes (diagnostic use)</term><term>neurophysiology</term><term>orthostatic tremor</term><term>pathophysiology</term><term>prognosis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Neurophysiologie</term><term>Pathologie du système nerveux</term><term>Photon</term><term>Physiopathologie</term><term>Pronostic</term><term>Tomoscintigraphie émission monophotonique</term><term>Tremblement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Involvement of the dopaminergic system in orthostatic tremor is controversial. The aim of this study was to detect possible dopaminergic denervation in primary orthostatic tremor (OT). Twelve consecutive patients with a firm diagnosis of primary orthostatic tremor were compared with age‐matched normal controls. All the patients had a neurological examination, surface polymyography, and quantification of striatal dopamine transporters with 123I‐FP‐CIT SPECT imaging. There was no significant difference in 123I‐FP‐CIT SPECT findings between controls and patients with OT. Longstanding primary orthostatic tremor is not necessarily associated with 123I‐FP‐CIT SPECT abnormalities, as 8 of our patients had more than a 10‐year history of OT. Primary orthostatic tremor without dopaminergic denervation remains a valid entity, although representing only a subtype of high‐frequency OT. A new role may emerge for 123I‐FP‐CIT SPECT in distinguishing between patients whose symptoms will be restricted to OT throughout the disease course and patients at an increased risk of developing PD. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Orsay</li><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Trocello, Jean Arc" sort="Trocello, Jean Arc" uniqKey="Trocello J" first="Jean-Marc" last="Trocello">Jean-Marc Trocello</name></noRegion><name sortKey="Apartis, Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name><name sortKey="Apartis, Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name><name sortKey="Devaux, Jean Ves" sort="Devaux, Jean Ves" uniqKey="Devaux J" first="Jean-Yves" last="Devaux">Jean-Yves Devaux</name><name sortKey="Habert, Marie Dile" sort="Habert, Marie Dile" uniqKey="Habert M" first="Marie-Odile" last="Habert">Marie-Odile Habert</name><name sortKey="Legrand, Andre Ierre" sort="Legrand, Andre Ierre" uniqKey="Legrand A" first="André-Pierre" last="Legrand">André-Pierre Legrand</name><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name><name sortKey="Trocello, Jean Arc" sort="Trocello, Jean Arc" uniqKey="Trocello J" first="Jean-Marc" last="Trocello">Jean-Marc Trocello</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><name sortKey="Zanotti Regonara, Paolo" sort="Zanotti Regonara, Paolo" uniqKey="Zanotti Regonara P" first="Paolo" last="Zanotti-Fregonara">Paolo Zanotti-Fregonara</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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